API TR 400-1993

$20.15

A Preliminary Study of the Effect of Toluene on Pregnancy of the Rat (Inhalation exposure)

Published By	Publication Date	Number of Pages
API	1993	106

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Description

This report describes a preliminary experiment performed in the pregnant rat to determine appropriate exposure levels of Toluene, a solvent, for futureinvestigation of embryofoetal toxicity in the rat when administered via the inhalation route from Days 6 to 15 of pregnancy inclusive.

The inhalation route of administration, waschosen by the Sponsor as themost likely route of exposure to man. The exposure levels were chosen bythe Sponsor following a review of currently available information.

Toluene was supplied from BDH Ltd., in fifty-seven 2.5 litre bottles. Itwas suppliedas a clear colorless liquid, purity 99.9%, batchnumber 2212770L and was received in these laboratories on 16 July 1990, andwas stored in the dark under ambient temperature. This batch was usedthroughout the study.

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